| Primary Identifier | MGI:5637816 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | App |
| Transmission | Germline | Strain of Origin | C57BL/6NTac |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The sequence of exon 16 was humanized by the introduction of the Swedish mutations (p.KM670_671delinsNL) and exon 17 by the introduction of the Beyreuther/Iberian mutation (p.I716F). A loxP site flanked neomycin resistance gene cassette was inserted in intron 16 and subsequently removed through Cre-mediated recombination. |
