| First Author | Lindberg N | Year | 2009 |
| Journal | Oncogene | Volume | 28 |
| Issue | 23 | Pages | 2266-75 |
| PubMed ID | 19421151 | Mgi Jnum | J:151346 |
| Mgi Id | MGI:4353574 | Doi | 10.1038/onc.2009.76 |
| Citation | Lindberg N, et al. (2009) Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma. Oncogene 28(23):2266-75 |
| abstractText | Gliomas are primary brain tumors mainly affecting adults. The cellular origin is unknown. The recent identification of tumor-initiating cells in glioma, which share many similarities with normal neural stem cells, has suggested the cell of origin to be a transformed neural stem cell. In previous studies, using the RCAS/tv-a mouse model, platelet-derived growth factor B (PDGF-B)-induced gliomas have been generated from nestin or glial fibrillary acidic protein-expressing cells, markers of neural stem cells. To investigate if committed glial progenitor cells could be the cell of origin for glioma, we generated the Ctv-a mouse where tumor induction would be restricted to myelinating oligodendrocyte progenitor cells (OPCs) expressing 2',3'-cyclic nucleotide 3'-phosphodiesterase. We showed that PDGF-B transfer to OPCs could induce gliomas with an incidence of 33%. The majority of tumors resembled human WHO grade II oligodendroglioma based on close similarities in histopathology and expression of cellular markers. Thus, with the Ctv-a mouse we have showed that the cell of origin for glioma may be a committed glial progenitor cell. |
