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Allele : Gt(ROSA)26Sor<tm5(ASPSCR1/TFE3)Mrc> gene trap ROSA 26, Philippe Soriano; targeted mutation 5, Mario R Capecchi

Primary Identifier  MGI:5649273 Allele Type  Targeted
Attribute String  Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter Gene  Gt(ROSA)26Sor
Transmission  Germline Strain of Origin  (129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Is Recombinase  false Is Wild Type  false
molecularNote  A cDNA clone was produced using RNA purified from a confirmed alveolar soft part sarcoma tumor. The cDNA contained the ASPCR1/TFE3 fusion product of the t(X;17) chromosomal translocation typical of these tumors. This cDNA was inserted downstream of a floxed STOP sequence consisting of the neomycin resistance gene and a polyadenylation transcription termination sequence and upstream of an IRES-EGFP. Both the fusion gene and EGFP will be translated form the same transcript following cre-mediated recombination to remove the STOP.
  • mutations:
  • Insertion
  • synonyms:
  • Rosa26-LSL-AT3,
  • Rosa26-LSL-AT3
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

5 Publication categories