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Allele : Map3k1<tm1Ega> mitogen-activated protein kinase kinase kinase 1; targeted mutation 1, Ewen Gallagher
Primary Identifier  MGI:5660414 Allele Type  Targeted
Attribute String  Hypomorph Gene  Map3k1
Transmission  Germline Strain of Origin  Not Specified
Is Recombinase  false Is Wild Type  false
molecularNote  A floxed neo cassette was inserted in intron 6 and a mutated exon 7 replaced exon 7 via homologous recombination. The mutated exon 7 contains substitutions of C438 and I440 with alanines. This mutation inactivates the plant homeodomain (PHD) motif and impairs E3 Ub ligase activity.
  • mutations:
  • Insertion
  • synonyms:
  • Map3k1<mPHD>,
  • Map3k1<mPHD>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

3 Publication categories





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