Primary Identifier | MGI:5688497 | Allele Type | Chemically induced (ENU) |
Gene | Cd22 | Inheritance Mode | Recessive |
Strain of Origin | C57BL/6J | Is Recombinase | false |
Is Wild Type | false | Project Collection | Beutler Mutagenetix |
molecularNote | ENU mutagenesis induced a G to A transition at base pair 30,870,105 (v38) on chromosome 7, or base pair 10,238 in the GenBank genomic region NC_000073. The mutation corresponds to residue 1,948 in the mRNA sequence NM_001043317 (variant 1) within exon 10 of 16 total exons and to residue 1,823 in the mRNA sequence NM_009845 (variant 2) within exon 8 of 14 total exons. The mutated nucleotide is indicated in red. The mutation results in a valine (V) to methionine (M) substitution at position 529 (V529M) in both isoforms. |