| Primary Identifier | MGI:5691395 | Allele Type | Targeted |
| Attribute String | Conditional ready, Hypomorph | Gene | Isl1 |
| Transmission | Germline | Strain of Origin | Not Specified |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 4, which encodes the homeodomain of the protein product, was floxed by the insertion of a loxP site on one end and a loxP site and frt-flanked neo cassette on the other end. This allele was used to generate Isl1tm2Sev and Isl1tm2.1Sev. Immunohistochemistry confirmed reduced protein expression in the spinal cord. |
