| First Author | Miller MS | Year | 2015 |
| Journal | Nat Immunol | Volume | 16 |
| Issue | 5 | Pages | 485-94 |
| PubMed ID | 25822250 | Mgi Jnum | J:231861 |
| Mgi Id | MGI:5775264 | Doi | 10.1038/ni.3132 |
| Citation | Miller MS, et al. (2015) Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis. Nat Immunol 16(5):485-94 |
| abstractText | The human helicase senataxin (SETX) has been linked to the neurodegenerative diseases amyotrophic lateral sclerosis (ALS4) and ataxia with oculomotor apraxia (AOA2). Here we identified a role for SETX in controlling the antiviral response. Cells that had undergone depletion of SETX and SETX-deficient cells derived from patients with AOA2 had higher expression of antiviral mediators in response to infection than did wild-type cells. Mechanistically, we propose a model whereby SETX attenuates the activity of RNA polymerase II (RNAPII) at genes stimulated after a virus is sensed and thus controls the magnitude of the host response to pathogens and the biogenesis of various RNA viruses (e.g., influenza A virus and West Nile virus). Our data indicate a potentially causal link among inborn errors in SETX, susceptibility to infection and the development of neurologic disorders. |
