| Primary Identifier | MGI:5701634 | Allele Type | Targeted |
| Gene | Sh3bp2 | Transmission | Germline |
| Strain of Origin | 129S2/SvPas | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | A targeting vector was designed to introduce a GGA to CGA mutation in exon 9, resulting in a glycine to arginine substitution at position 418 (G418R), and a floxed neomycin resistance cassette. The floxed neomycin resistance cassette was removed via cre-mediated recombination. The murine G418R mutation is analogous to the G420R mutation frequently seen in human cherubic patients. |
