| First Author | Vogel P | Year | 2015 |
| Journal | Vet Pathol | Volume | 52 |
| Issue | 1 | Pages | 224-9 |
| PubMed ID | 24686385 | Mgi Jnum | J:227246 |
| Mgi Id | MGI:5699959 | Doi | 10.1177/0300985814528218 |
| Citation | Vogel P, et al. (2015) Malformation of incisor teeth in Grem2(-)/(-) mice. Vet Pathol 52(1):224-9 |
| abstractText | GREMLIN 2 (GREM2)--formerly, protein related to Dan and cerberus (PRDC)-is a potent antagonist of the bone morphogenetic proteins 2 and 4, but little else in known about its functions. We found that Grem2(-/-) mice developed small deformed mandibular and maxillary incisors, indicating that GREMLIN2 is required for normal tooth morphogenesis. Although DEXA scans suggested that bone mineral density might be increased in Grem2(-/-) mice, histology did not reveal any evident bone phenotype. Grem2(-/-) mice did not display any other notable phenotypes evaluated in a high-throughput screening process that encompassed a range of immunologic, metabolic, ophthalmic, and behavioral parameters. Our findings indicate that Grem2 can be added to the growing list of genes that affect tooth development in mice. |
