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Allele : Ube3a<tm1Yelg> ubiquitin protein ligase E3A; targeted mutation 1, Ype Elgersma

Primary Identifier  MGI:5704099 Allele Type  Targeted
Attribute String  Conditional ready, Hypomorph Gene  Ube3a
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  false Is Wild Type  false
molecularNote  A neomycin-stop cassette flanked by loxP sites was inserted into intron 3 via homologous recombination. Cre-mediated recombination can be used to reinstate gene expression. Western blot analysis of hippocampus, cortex, and cerebellum in mice with a maternally inherited allele show a severe decrease in protein levels.
  • mutations:
  • Insertion
  • synonyms:
  • Ube3a<stop>,
  • Ube3a<stop>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

11 Publication categories