| First Author | Hortle E | Year | 2019 |
| Journal | Sci Rep | Volume | 9 |
| Issue | 1 | Pages | 6356 |
| PubMed ID | 31015511 | Mgi Jnum | J:280817 |
| Mgi Id | MGI:6357239 | Doi | 10.1038/s41598-019-42782-x |
| Citation | Hortle E, et al. (2019) KCC1 Activation protects Mice from the Development of Experimental Cerebral Malaria. Sci Rep 9(1):6356 |
| abstractText | Plasmodium falciparum malaria causes half a million deaths per year, with up to 9% of this mortality caused by cerebral malaria (CM). One of the major processes contributing to the development of CM is an excess of host inflammatory cytokines. Recently K+ signaling has emerged as an important mediator of the inflammatory response to infection; we therefore investigated whether mice carrying an ENU induced activation of the electroneutral K+ channel KCC1 had an altered response to Plasmodium berghei. Here we show that Kcc1(M935K/M935K) mice are protected from the development of experimental cerebral malaria, and that this protection is associated with an increased CD4+ and TNFa response. This is the first description of a K+ channel affecting the development of experimental cerebral malaria. |
