| First Author | Ryu YC | Year | 2023 |
| Journal | Cells | Volume | 12 |
| Issue | 4 | PubMed ID | 36831222 |
| Mgi Jnum | J:355748 | Mgi Id | MGI:7440424 |
| Doi | 10.3390/cells12040555 | Citation | Ryu YC, et al. (2023) CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD(2). Cells 12(4) |
| abstractText | The number of people suffering from hair loss is increasing, and hair loss occurs not only in older men but also in women and young people. Prostaglandin D(2) (PGD(2)) is a well-known alopecia inducer. However, the mechanism by which PGD(2) induces alopecia is poorly understood. In this study, we characterized CXXC5, a negative regulator of the Wnt/beta-catenin pathway, as a mediator for hair loss by PGD(2). The hair loss by PGD(2) was restored by Cxxc5 knock-out or treatment of protein transduction domain-Dishevelled binding motif (PTD-DBM), a peptide activating the Wnt/beta-catenin pathway via interference with the Dishevelled (Dvl) binding function of CXXC5. In addition, suppression of neogenic hair growth by PGD(2) was also overcome by PTD-DBM treatment or Cxxc5 knock-out as shown by the wound-induced hair neogenesis (WIHN) model. Moreover, we found that CXXC5 also mediates DHT-induced hair loss via PGD(2). DHT-induced hair loss was alleviated by inhibition of both GSK-3beta and CXXC5 functions. Overall, CXXC5 mediates the hair loss by the DHT-PGD(2) axis through suppression of Wnt/beta-catenin signaling. |
