| Primary Identifier | MGI:5707260 | Allele Type | Targeted |
| Attribute String | Hypomorph, Modified regulatory region | Gene | Pgr |
| Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A Ser191 phosphorylation site in exon 1 was mutated to alanine and an FRT flaked neo cassette was inserted in intron 1 via homologous recombination. Flp mediated recombination removed the neo cassette. Immunoblot analysis indicates that protein expression is similar to that of the wild-type allele. Chromatin immunoprecipitation analysis indicates reduced binding activity to some enhancers. |
