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Allele : Tg(Itgam-cre/ERT2,U6-RNAi:Cacna1b)17Ttan transgene insertion 17, Tsutomu Tanabe
Primary Identifier  MGI:5705582 Allele Type  Transgenic
Attribute String  Inducible, Knockdown, Recombinase Gene  Tg(Itgam-cre/ERT2,U6-RNAi:Cacna1b)17Ttan
Strain of Origin  C57BL/6J Induced With  tamoxifen
Is Recombinase  true Is Wild Type  false
molecularNote  The transgene is composed of the human RNU6 promoter disrupted by a floxed neomycin resistance cassette, short-hairpin RNA targeting Cacna1b, the human GH sequence, and the mouse Itgam promoter driving expression of an inducible cre recombinase gene (cre/ERT2) in microglial/macrophage cells. Five founders were generated and line 17 was selected as the representative line.
  • mutations:
  • Insertion
  • synonyms:
  • Cav2.2KD,
  • Cav2.2KD,
  • Tg(Itgam-cre/ERT2,RNU6-RNAi:Cacna1b)17Ttan,
  • Tg(Itgam-cre/ERT2,RNU6-RNAi:Cacna1b)17Ttan
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1 Feature

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1 Mutation Involves

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Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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1 Driven By

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