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Allele : Ppp5c<tm1.1Ptwc> protein phosphatase 5, catalytic subunit; targeted mutation 1.1, Patricia TW Cohen
Primary Identifier  MGI:5708332 Allele Type  Targeted
Gene  Ppp5c Transmission  Germline
Strain of Origin  Not Specified Is Recombinase  false
Is Wild Type  false
molecularNote  A GAC to GCT codon change was inserted in exon 7 and an FRT flanked neo cassette was inserted in intron 6 via homologous recombination. The condon change results in an Asp274Ala substitution. Flp mediated recombination removed the neo cassette. Immunoblot analysis detected the presence of the 58 kDa form but not the cleaved 50kDa form in liver lysates from homozygous mice. The mutant protein lacks protein phosphatase activity.
  • mutations:
  • Single point mutation,
  • Insertion
  • synonyms:
  • Ppp5<D274A>,
  • Ppp5<D274A>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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3 Publication categories

Trail: Allele




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