| Primary Identifier | MGI:5708345 | Allele Type | Spontaneous |
| Attribute String | Hypomorph | Gene | Dsg3 |
| Inheritance Mode | Recessive | Strain of Origin | C57BL/6 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A 1092 bp deletion was identified in the region between the 3' end of intron 5 and part of exon 7. The deletion removes all of exon 6, intron 6 and 12 codons of exon 7. The mutant protein has a loss of 69 amino acids within the extracellular cadherin domain 2 (EC2). Real-time quantitative PCR and Western blot analyses indicated similar levels of transcript expression but reduced levels of protein expression compared to the wild-type protein. |
