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Allele : Des<tm1.1Ccrs> desmin; targeted mutation 1.1, Christoph S Clemen and Rolf Schroder
Primary Identifier  MGI:5708562 Allele Type  Targeted
Gene  Des Transmission  Germline
Strain of Origin  129 Is Recombinase  false
Is Wild Type  false
molecularNote  An R349P mutation (AGG to CCC) was inserted in exon 6 and a floxed neo cassette was inserted in intron 6 via homologous recombination. Cre mediated recombination removed the neo cassette. Immunoblot analysis indicates severely reduced expression of the mutant protein.
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • Des<tm1(R349P)Cscl&Rfsr>,
  • Des<tm1(R349P)Cscl&Rfsr>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

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0 Driven By

8 Publication categories

Trail: Allele




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