| Primary Identifier | MGI:5749799 | Allele Type | Targeted |
| Attribute String | Hypomorph | Gene | Nefl |
| Transmission | Germline | Strain of Origin | (C57BL/6J x 129S6/SvEvTac)F1 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | An N98S (AAC>AGC) mutation was inserted in exon 1 and a floxed neo cassette was inserted in intron 1 via homologous recombination. Cre mediated recombination removed the neo cassette. Protein levels are decreased approximately 30% in the brains and spinal cords of heterozygous mice compared to wild-type controls. Protein levels in the sciatic nerves of heterozygous mice are decreased ~80% compared to wild-type controls. |
