| Primary Identifier | MGI:5750894 | Allele Type | Targeted |
| Gene | Lrrk2 | Transmission | Germline |
| Strain of Origin | B6.Cg-Thy1<a> | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Exon 41 was replaced with a modified exon 41 with nucleotide substitutions (GGG to AGC) that results in the substitution of serine for glycine at position 2019 (G2019S). A floxed neomycin cassette was placed immediately downstream of exon 41 and was removed via cre-mediated recombination. Kinase activity is increased about 1.8-fold in heterozygotes and about 4-fold in homozygotes. |
