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Allele : Ifng<tm1.1Hayg> interferon gamma; targeted mutation 1.1, Howard A Young
Primary Identifier  MGI:5751448 Allele Type  Targeted
Gene  Ifng Transmission  Germline
Strain of Origin  (C57BL/6J x 129S4/SvJae)F1 Is Recombinase  false
Is Wild Type  false
molecularNote  A loxP site flanked neomycin resistance gene cassette replaced 162 nt of the adenylate-uridylate rich element (ARE) sequence. Cre-mediated recombination removed the neo cassette. Deletion of the ARE increases the half-life of the mRNA and results in constitutive expression of a low level of IFN-gamma under normal physiologic conditions.
  • mutations:
  • Intragenic deletion,
  • Insertion
  • synonyms:
  • ARE-del,
  • ARE-del
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

19 Publication categories





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