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Allele : Psen1<tm4.1Shn> presenilin 1; targeted mutation 4.1, Jie Shen
Primary Identifier  MGI:5751732 Allele Type  Targeted
Gene  Psen1 Transmission  Germline
Strain of Origin  (C57BL/6 x 129)F1 Is Recombinase  false
Is Wild Type  false
molecularNote  An L435F (1303C to T) mutation was inserted in exon 12 and a floxed neo cassette was inserted in intron 11 via homologous recombination. Cre mediated recombination removed the neo cassette. The mutation in exon 12 severely impairs gamma-secretase activity.
  • mutations:
  • Single point mutation,
  • Insertion
  • synonyms:
  • L435F,
  • L435F
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

5 Publication categories





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