| First Author | Banerjee S | Year | 2014 |
| Journal | Nat Commun | Volume | 5 |
| Pages | 5759 | PubMed ID | 25536025 |
| Mgi Jnum | J:225389 | Mgi Id | MGI:5693211 |
| Doi | 10.1038/ncomms6759 | Citation | Banerjee S, et al. (2014) Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour. Nat Commun 5:5759 |
| abstractText | Synthetic drug-like molecules that directly modulate the activity of key clock proteins offer the potential to directly modulate the endogenous circadian rhythm and treat diseases associated with clock dysfunction. Here we demonstrate that synthetic ligands targeting a key component of the mammalian clock, the nuclear receptors REV-ERBalpha and beta, regulate sleep architecture and emotional behaviour in mice. REV-ERB agonists induce wakefulness and reduce REM and slow-wave sleep. Interestingly, REV-ERB agonists also reduce anxiety-like behaviour. These data are consistent with increased anxiety-like behaviour of REV-ERBbeta-null mice, in which REV-ERB agonists have no effect. These results indicate that pharmacological targeting of REV-ERB may lead to the development of novel therapeutics to treat sleep disorders and anxiety. |
