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Allele : Malt1<tm2Jrld> MALT1 paracaspase; targeted mutation 2, Jurgen Ruland

Primary Identifier	MGI:5752604	Allele Type	Targeted
Gene	Malt1	Transmission	Germline
Strain of Origin	129P2/OlaHsd	Is Recombinase	false
Is Wild Type	false

molecularNote

Exon 11 was replaced with a floxed neomycin resistance cassette and a modified exon 11 in which nucleotide substitution (TGT CGC to GCG CGC) results in the amino acid substitution of alanine for arginine at position 473 (R47A).

mutations:
Insertion,
Nucleotide substitutions

cellLines:
Not Specified

synonyms:
Malt1<rec>,
Malt1<rec>,
Malt1<rec>

earliestPublication:
Gewies A, et al. (2014) Uncoupling Malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation. Cell Rep 9(4):1292-305

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

3 Publication categories

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