Primary Identifier | MGI:5763757 | Allele Type | Chemically induced (ENU) |
Attribute String | Hypomorph | Gene | Kl |
Inheritance Mode | Recessive | Strain of Origin | C57BL/6J |
Is Recombinase | false | Is Wild Type | false |
molecularNote | ENU mutagenesis induced a C to T transition in exon 1 that results in the generation of a stop codon at position 203. This mutation, located in the KL1 domain, is severely hypomorphic and leads to a 17-fold reduction in renal expression, as determined by qRT-PCR analysis. |