| Primary Identifier | MGI:5770425 | Allele Type | Targeted |
| Gene | Stk39 | Transmission | Germline |
| Strain of Origin | Not Specified | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | Exon 16 was replaced with a modified exon 16 in which nucleotide substitutions result in the amino acid substitution of alanine for leucine at position 502 (L502A) in the conserved carboxy-terminal (CCT) domain. Flp-mediated recombination removed an FRT-flanked puromycin cassette inserted in intron 15. This mutation suppresses protein phosphorylation by WNK isoforms and results in markedly reduced phosphorylation and expression of sodium ion co-transporters NCC and NKCC2 in the kidney. |
