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Allele : Chrna5<tm1.1Itl> cholinergic receptor, nicotinic, alpha polypeptide 5; targeted mutation 1.1, inGenious Targeting Laboratory

Primary Identifier  MGI:5767316 Allele Type  Targeted
Attribute String  Dominant negative Gene  Chrna5
Transmission  Germline Strain of Origin  C57BL/6
Is Recombinase  false Is Wild Type  false
molecularNote  A G to A point mutation results in the amino acid substitution of asparagine for aspartic acid at position 397 (D397N). This mutation results in a dominant negative. The neomycin resistance cassette was removed. This nonsynonymous engineered SNP is equivalent to the human SNP rs16969968
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • alpha5DN,
  • alpha5DN
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

4 Publication categories