Primary Identifier | MGI:5774860 | Allele Type | Transgenic |
Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(Thy1-MAPT*L266V*G272V)13Ema |
Strain of Origin | (C57BL/6 x DBA/2)F1 | Is Recombinase | false |
Is Wild Type | false |
molecularNote | The human Tau containing three ~32 amino acid repeats bearing the L266V and G272V mutations associated with familial forms of Picks Disease is under the control of the neuronal mouse Thy1 promoter. Line 13 is a high expressing line and expresses 8 fold higher levels than line 2. |