Primary Identifier | MGI:5776502 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Sorbs2 |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The targeting vector was designed with a loxP::frt-SV40 promoter-Neo-pA-frt cassette 389 bp upstream of exon 12, and a loxP site 676 bp downstream of exon 12. Cre-mediated recombination removed exon 12. Western blot analysis of heart and brain tissues confirmed that no protein was expressed in mutant mice. |