Primary Identifier | MGI:5787927 | Allele Type | Targeted |
Gene | Emg1 | Transmission | Germline |
Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> | Is Recombinase | false |
Is Wild Type | false |
molecularNote | Exon 2 was replaced with a modified one containing an A to G point mutation that reasults in the amino acid substitution of glycine for aspartic acid at position 86 (D86G). This mutation is associated with Bowen-Conradi syndrome (BCS). Flp-mediated recombination removed the inserted splice acceptor IRES beta-geo cassette. |