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Allele : Pik3cb<tm2.1Bvan> phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; targeted mutation 2.1, Bart Vanhaesebroeck
Primary Identifier  MGI:5788280 Allele Type  Targeted
Attribute String  Not Specified Gene  Pik3cb
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  false Is Wild Type  false
molecularNote  The targeting construct inserted after the STOP codon in the last exon (24) a loxP site, IRES sequence, lacZ reporter gene, neomycin resistance cassette and loxP site. Exon 22 was modified by nucleotide substitutions to accomplish the amino acid substitution of alanine for aspartic acid at position 931 (D931A). Cre-mediated recombination removed the reporter/selection cassette.
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • p110beta<D931A>,
  • p110beta<D931A>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

3 Carried By

0 Driven By

3 Publication categories





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