| First Author | Habif JC | Year | 2023 |
| Journal | Development | Volume | 150 |
| Issue | 2 | PubMed ID | 36661357 |
| Mgi Jnum | J:333403 | Mgi Id | MGI:7438081 |
| Doi | 10.1242/dev.201116 | Citation | Habif JC, et al. (2023) The role of a ciliary GTPase in the regulation of neuronal maturation of olfactory sensory neurons. Development 150(2):dev201116 |
| abstractText | Olfactory sensory neurons (OSNs) form embryonically and mature perinatally, innervating glomeruli and extending dendrites with multiple cilia. This process and its timing are crucial for odor detection and perception and continues throughout life. In the olfactory epithelium (OE), differentiated OSNs proceed from an immature (iOSN) to a mature (mOSN) state through well-defined sequential morphological and molecular transitions, but the precise mechanisms controlling OSN maturation remain largely unknown. We have identified that a GTPase, ARL13B, has a transient and maturation state-dependent expression in OSNs marking the emergence of a primary cilium. Utilizing an iOSN-specific Arl13b-null murine model, we examined the role of ARL13B in the maturation of OSNs. The loss of Arl13b in iOSNs caused a profound dysregulation of the cellular homeostasis and development of the OE. Importantly, Arl13b null OSNs demonstrated a delay in the timing of their maturation. Finally, the loss of Arl13b resulted in severe deformation in the structure and innervation of glomeruli. Our findings demonstrate a previously unknown role of ARL13B in the maturation of OSNs and development of the OE. |
