|  Help  |  About  |  Contact Us

Allele : Tlr4<Lps-8Btlr> toll-like receptor 4; defective lipopolysaccharide response 8 Bruce Beutler

Primary Identifier  MGI:5789549 Allele Type  Chemically induced (ENU)
Attribute String  Not Specified Gene  Tlr4
Inheritance Mode  Semidominant Strain of Origin  C57BL/6J
Is Recombinase  false Is Wild Type  false
Project Collection  Beutler Mutagenetix
molecularNote  ENU-induced A to T transversion at base pair 66,839,303 (v38) on chromosome 4, or base pair 11,493 in the GenBank genomic region NC_000070 for the Tlr4 gene. The mutation corresponds to residue 613 in the mRNA sequence NM_021297.2 within exon 3 of 3 total exons. The mutation results in an asparagine (N) to isoleucine (I) substitution at position 111 (N111I) in the protein.
  • mutations:
  • Single point mutation
  • synonyms:
  • Guardiola,
  • Guardiola
Quick Links:
 
Quick Links:
 

1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

3 Publication categories

Trail: Allele