Primary Identifier | MGI:5789569 | Allele Type | Chemically induced (ENU) |
Attribute String | Not Specified | Gene | Nlrp3 |
Inheritance Mode | Semidominant | Strain of Origin | C57BL/6J |
Is Recombinase | false | Is Wild Type | false |
Project Collection | Beutler Mutagenetix |
molecularNote | ENU-induced C to T transition at base pair 59,548,010 (v38) on chromosome 11, or base pair 6,442 in the GenBank genomic region NC_000077. The mutation corresponds to residue 638 in the mRNA sequence NM_145827 within exon 4 of 10 total exons. The mutation results in substitution of arginine (R) 138 to a premature stop codon (R138*) in the protein. |