| Help | About | Contact Us

Allele : Npc1l1<tm1Stky> NPC1 like intracellular cholesterol transporter 1; targeted mutation 1, Hiroshi Suzuki

Primary Identifier	MGI:5792802	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Npc1l1
Transmission	Germline	Strain of Origin	C57BL/6J
Is Recombinase	false	Is Wild Type	false

molecularNote

A neomycin resistance cassette replaced exons 1 and 2 and part of the promoter region. Western blot analysis confirmed the absence of protein expression in the intestine.

mutations:
Intragenic deletion,
Insertion

cellLines:
Not Specified

synonyms:
Npc1l1KO3TY/UT,
Npc1l1KO3TY/UT

earliestPublication:
Takada T, et al. (2015) NPC1L1 is a key regulator of intestinal vitamin K absorption and a modulator of warfarin therapy. Sci Transl Med 7(275):275ra23

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

0 Carried By

0 Driven By

4 Publication categories

Questions? Comments? Click here!

MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Your name:
Your email address:
Subject:
Message:	---- Current page: ---- /mousemine/report.do?id=76586852

MouseMine