| Primary Identifier | MGI:5803807 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inducible, Inserted expressed sequence | Gene | Tg(tetO/Prnp-APP*Swe*Lon)9191Krz |
| Strain of Origin | FVB/N | Induced With | doxycycline/tetracycline |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The 695 amino acid isoform of human amyloid precursor protein with the Swedish (K670N and M671L) and London (V717I) mutations is under the control of the tetracycline-response element and the Prnp promoter. Western blot analysis indicate transgene expression at a level four times that of the endogenous mouse protein in the membrane-enriched fraction of the brain. |
