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Publication : Metabolic alterations caused by the mutation and overexpression of the <i>Tmem135</i> gene.

First Author  Lee WH Year  2020
Journal  Exp Biol Med (Maywood) Volume  245
Issue  17 Pages  1571-1583
PubMed ID  32515224 Mgi Jnum  J:326367
Mgi Id  MGI:6874315 Doi  10.1177/1535370220932856
Citation  Lee WH, et al. (2020) Metabolic alterations caused by the mutation and overexpression of the Tmem135 gene. Exp Biol Med (Maywood) 245(17):1571-1583
abstractText  IMPACT STATEMENT: Mitochondria are dynamic organelles undergoing fission and fusion. Proper regulation of this process is important for healthy aging process, as aberrant mitochondrial dynamics are associated with several age-related diseases/pathologies. However, it is not well understood how imbalanced mitochondrial dynamics may lead to those diseases and pathologies. Here, we aimed to determine metabolic alterations in tissues and cells from mouse models with over-fused (fusion > fission) and over-fragmented (fusion < fission) mitochondria that display age-related disease pathologies. Our results indicated tissue-dependent sensitivity to these mitochondrial changes, and metabolic pathways likely affected by aberrant mitochondrial dynamics. This study provides new insights into how dysregulated mitochondrial dynamics could lead to functional abnormalities of tissues and cells.
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