| Primary Identifier | MGI:5806239 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Atm |
| Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Two loxP sites were inserted into the introns surrounding to exon 4. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted into intron 3. Cre-mediated recombination removed exon 4. This allele is predicted to cause a frameshift mutation through the splicing of exon 3 to exon 5. Western blot analysis confirmed the absence of protein expression in fibroblasts. |
