| Primary Identifier | MGI:5817407 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(PMP22)C22Fbas |
| Strain of Origin | (C57BL/6J x CBA/Ca)F1 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | A yeast artificial chromosome (YAC) library was used to obtain a 560 kb BAC (49G7, also called 49H7) containing the entire human peripheral myelin protein 22 (PMP22) gene. Founder line C22 and carries 7 copies of the YAC, resulting in a more severe phenotype than the lower copy number line C3 mice. Overexpression of PMP22 is associated with Charcot-Marie-Tooth disease type 1A (CMT1A). |
