| Primary Identifier | MGI:5816715 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Ccp110 |
| Transmission | Germline | Strain of Origin | Not Specified |
| Is Recombinase | false | Is Wild Type | false |
| description | Phenotypic Similarity to Human Syndrome: Short Rib-Polydactyly Syndrome (J:232855). |
| molecularNote | Exon 5 was flanked by loxP sites. An FRT-flanked neomycin selection cassette was removed by breeding heterozygous floxed animals with actin-Flp recombinase mice, and the loxP-flanked exon 5 sequences were removed by breeding with zona pellucida promoter-driven Cre mice which express Cre in developing oocytes. Immunoblot analysis using anti-CP110 antibody on protein extracts confirmed the absence of protein expression in E14.5 homozygous mutant embryos. |
