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Allele : Tg(Col1a1-Dkk1)1Hmk transgene insertion 1, Henry M Kronenberg

Primary Identifier	MGI:5818202	Allele Type	Transgenic
Attribute String	Inserted expressed sequence	Gene	Tg(Col1a1-Dkk1)1Hmk
Strain of Origin	FVB/N	Is Recombinase	false
Is Wild Type	false

molecularNote

A 2.3 kb promoter fragment of mouse Col1a1 was used to drive expression of the entire coding region of the mouse Dkk1 gene. Transgene expression is directed to osteoblastic lineage cells.

mutations:
Insertion

synonyms:
Dkk1-tg,
Col1alpha2.3-Dkk1,
Col1alpha-Dkk1,
Col1alpha2.3-Dkk1,
Col1alpha-Dkk1,
Dkk1-tg

earliestPublication:
Fleming HE, et al. (2008) Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo. Cell Stem Cell 2(3):274-83

1 Feature

Genome

1 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

2 Carried By

0 Driven By

5 Publication categories

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