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Allele : Crh<tm2.1Maj> corticotropin releasing hormone; targeted mutation 2.1, Joseph Majzoub

Primary Identifier	MGI:5819101	Allele Type	Targeted
Attribute String	Conditional ready, No functional change	Gene	Crh
Transmission	Germline	Strain of Origin	129S4/SvJae
Is Recombinase	false	Is Wild Type	false

molecularNote

A loxP site was introduced to intron 1 and a FRT-flanked neomycin cassette followed by a loxP site was placed in intron 2. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 2 floxed.

mutations:
Insertion

cellLines:
Not Specified

synonyms:
Crh flox,
Crh flox

earliestPublication:
Zhang R, et al. (2017) Loss of hypothalamic corticotropin-releasing hormone markedly reduces anxiety behaviors in mice. Mol Psychiatry 22(5):733-744

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

7 Publication categories

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