| First Author | Bhakar AL | Year | 2002 |
| Journal | J Neurosci | Volume | 22 |
| Issue | 19 | Pages | 8466-75 |
| PubMed ID | 12351721 | Mgi Jnum | J:79207 |
| Mgi Id | MGI:2387507 | Doi | 10.1523/JNEUROSCI.22-19-08466.2002 |
| Citation | Bhakar AL, et al. (2002) Constitutive nuclear factor-kappa B activity is required for central neuron survival. J Neurosci 22(19):8466-75 |
| abstractText | The function of nuclear factor (NF)-kappaB within the developing and mature CNS is controversial. We have generated transgenic mice to reveal NF-kappaB transcriptional activity in vivo. As expected, constitutive NF-kappaB activity was observed within immune organs, and tumor necrosis factor-inducible NF-kappaB activity was present in mesenchymal cells. Intriguingly, NF-kappaB activity was also prominent in the CNS throughout development, especially within neocortex, olfactory bulbs, amygdala, and hippocampus. NF-kappaB in the CNS was restricted to neurons and blocked by overexpression of dominant-negative NF-kappaB-inducible kinase or the IkappaBalphaM super repressor. Blocking endogenous neuronal NF-kappaB activity in cortical neurons using recombinant adenovirus induced neuronal death, whereas induction of NF-kappaB activity increased levels of anti-apoptotic proteins and was strongly neuroprotective. Together, these data demonstrate a physiological role for NF-kappaB in maintaining survival of central neurons. |
