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Allele : Sirpa<Idd13.2-NOD/ShiLt> signal-regulatory protein alpha; insulin dependent diabetes susceptibility 13.2-NOD/ShiLt

Primary Identifier	MGI:5827684	Allele Type	QTL
Gene	Sirpa	Strain of Origin	NOD/ShiLt
Is Recombinase	false	Is Wild Type	false

molecularNote

There are 18 amino acid variations in the IgV domain between NOD and NOR strains thought to account for increased Cd47 affinity in NOD variant versus other strain variants.

earliestPublication:
Legrand N, et al. (2011) Functional CD47/signal regulatory protein alpha (SIRP(alpha)) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo. Proc Natl Acad Sci U S A 108(32):13224-9

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

5 Carried By

0 Driven By

8 Publication categories

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