| Primary Identifier | MGI:5882398 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Fcamr |
| Transmission | Germline | Strain of Origin | B6.Cg-Thy1<a> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | This allele was derived from Fcamrtm1Sjv by Cre recombinase-mediated deletion of a loxP-flanked DNA segment containing exon 4 and a FRT site-flanked selection cassette. Quantitative reverse transcription-PCR (qRT-PCR) analysis of total kidney RNA from homozygous mutant vs. wild-type mice demonstrated that the mutant RNA is present at ~45% of the wild-type level. These mice express a soluble form of the receptor that does not compete effectively in vitro with the native, membrane-bound receptor for binding to IgM monoclonal antibody. |
