| First Author | Jarvie BC | Year | 2017 |
| Journal | Nat Neurosci | Volume | 20 |
| Issue | 2 | Pages | 167-169 |
| PubMed ID | 27918529 | Mgi Jnum | J:239846 |
| Mgi Id | MGI:5881865 | Doi | 10.1038/nn.4451 |
| Citation | Jarvie BC, et al. (2017) HSD2 neurons in the hindbrain drive sodium appetite. Nat Neurosci 20(2):167-169 |
| abstractText | Sodium-depleted animals develop an appetite for aversive concentrations of sodium. Here we show that chemogenetic activation of aldosterone-sensitive neurons that express 11beta-hydroxysteroid dehydrogenase type 2 (HSD2) in the nucleus of the solitary tract is sufficient to drive consumption of sodium-containing solutions in mice, independently of thirst or hunger. These HSD2-positive neurons are necessary for full expression of sodium appetite and have distinct downstream targets that are activated during sodium depletion. |
