| Primary Identifier | MGI:5897172 | Allele Type | Transgenic |
| Attribute String | Conditional ready, Dominant negative, Inserted expressed sequence | Gene | Tg(CAG-Ppard*E411P)#Als |
| Strain of Origin | Not Specified | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | This transgene consists of a combined beta-actin promoter-cytomegalovirus enhancer, a STOP cassette flanked by loxP sites and the mouse Ppard cDNA with a single amino acid mutation, a substitution of proline for glutamate at residue 411 (E411P). Cre-mediated recombination can be used to remove the STOP cassette and express the mutant protein. This mutation inhibits Ppard transactivation in a dominant-negative manner. |
