| Primary Identifier | MGI:5903620 | Allele Type | Targeted |
| Attribute String | Hypomorph | Gene | Zap70 |
| Transmission | Germline | Strain of Origin | C57BL/6J |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A W131A (TGG->GCG, tryptophan to alanine) mutation was introduced into exon 2 and a neomycin cassette (flanked by loxP sites and inserted in reverse transcriptional orientation) was placed in intron 3. Cre-mediated recombination removed the floxed neo cassette. The mutation, located in interdomain A reduces protein expression by 50% in thymocytes and peripheral T cells. |
