| Primary Identifier | MGI:7779740 | Allele Type | Targeted |
| Attribute String | Humanized sequence | Gene | Scn2a |
| Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | Exon 7 was replaced with exon 7 containing human p.Ala263Val (A263V) gain-of-function mutation, a C to T substitution at position 788 (c.788C>T) and a loxP-flanked ACN cassette containing cre-recombinase under the control of the testes-specific promoter from the angiotensin-converting enzyme (tACE) and a Pol II-driven neomycin resistance gene. The tACE promoter allows expression of cre during spermatogenesis resulting in removal of the ACN cassette. |
