| Primary Identifier | MGI:5911621 | Allele Type | Targeted |
| Attribute String | Inducible, Recombinase | Gene | Agrp |
| Transmission | Germline | Strain of Origin | (129S6/SvEvTac x C57BL/6NCrl)F1 |
| Induced With | aminoglycosides | Is Recombinase | true |
| Is Wild Type | false |
| molecularNote | A cassette containing a nuclear localization signal, a mutated cre gene (nsCre) in which an in-frame nonsense mutation (TGA) was introduced into the position 837 of the coding region of the wild-type Cre recombinase gene, followed by frt-flanked neo gene was inserted just 5' of the initiation codon of the Agrp gene. Mutant mRNAs transcribed from nsCre transgene can be efficiently translated into full-length, functional Cre recombinase in the presence of nonsense suppressors such as aminoglycosides or synthetic homologs. |
