| Primary Identifier | MGI:7790611 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(CD2-TcraTrav16,H2-K1-TcrbTrbv5)R161HRrc |
| Strain of Origin | B10.RIII-H2<r> H2-T18<b>/(71NS)SnJ | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The transgene contains, TCR α and β chains were cloned from a highly uveitogenic T cell line, specific to the IRBP161â180 sequence, which encodes a major pathogenic epitope for B10.RIII mice, a strain highly susceptible to experimental autoimmune uveitis (EAU). The TCR a and b sequences were placed under control of the promoter and locus control region of the human CD2 gene, and the mouse H-2K promoter, respectively. This is high expressing line R161H having 5 TCR a and 8 TCR b tandem copies of the transgene inserted into the chromosome 9. |
